Carpal tunnel syndrome occurs when tendons or ligaments in the wrist become enlarged, often from inflammation, after being aggravated. This inflammation results in narrowing within the carpal tunnel, which may compress the median nerve. Symptoms may include burning, numbness/tingling in the fingers, and difficulty gripping or making a fist. Carpal tunnel commonly occurs as the result of repetitive wrist motions or gripping, with pregnancy, diabetes, and rheumatoid arthritis.